select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='35839' and ad.lang_id='3' and j.lang_id='3' and vi.lang_id='3' Efflux Pump Mediated Second-Line Tuberculosis Drug Resistanc | 35839
Микобактериальные заболевания

Микобактериальные заболевания
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ISSN: 2161-1068

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Efflux Pump Mediated Second-Line Tuberculosis Drug Resistance

Lesibana Anthony Malinga, Anton Stoltz and Martie van der Walt

The burden and spread of drug-resistant tuberculosis disease is a major public health problem worldwide. The causative agent, Mycobacterium tuberculosis uses several mechanisms to counteract therapy through drugresistance. A major and most common mechanism of drug-resistance is mediated through target mutations. Efflux pumps are emerging as potential agents of drug-resistance and treatment failure. In this review we explore the origin and principles of efflux pump-mediated resistance and determine their impact on second-line drugs used against extensively drug resistant tuberculosis. Inhibition of efflux pumps as a therapeutic intervention is also discussed.

Отказ от ответственности: Этот тезис был переведен с использованием инструментов искусственного интеллекта и еще не прошел рецензирование или проверку.
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