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Late Onset of Thoracic Aortic Disease Events after Abdominal Aortic Aneurysm Repair: Effect on Survival and Possible Associated Factors

Takuya Matsumoto, Eisuke Kawakubo, Daisuke Matsuda, Takeshi Takano, Jun Okadome, Koichi Morisaki, Ryota Fukunaga, Haidi Hu, Junji Kishimoto, Tomoko Ohkusa, Toshihiro Onohara and Yoshihiko Maehara

We investigated the possible relation between thoracic aortic disease events and long-term survival in patients after open Abdominal Aortic Aneurysm (AAA) repair, as well as factors associated with event occurrence. Pre-AAArepair demographic, comorbid, and laboratory variables in 48 patients who had an aortic dissection or thoracic aortic aneurysm up to 25 years after AAA repair were compared with the same variables in 522 patients without such an event. Survival rates at 5 and 10 years were 87% and 53%, respectively, in patients with a thoracic aortic event and 74% and 56% in those without an event (P=.7). Multivariate analysis showed that the risk of thoracic aortic events was increased by a high hemoglobin level, a high Fibrinogen Degradation Product (FDP) level, and a larger AAA diameter. The only factors significantly associated with thoracic aortic events were an AAA diameter of ≥ 55 mm and a high FDP level.