Журнал протеомики и биоинформатики
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Modeling of RNA Secondary Structure of Non Structural Gene and Evolutionary Stability of the Influenza Virus Through In Silico Methods

Pallavi Somvanshi, Vijai Singh and M. Arshad

An influenza virus is an important pathogen causing disease in the birds and further transmits to humans globally. The genome of Influenza virus encodes highly conserved non structural gene (NS1), which is thermodynamically stable in the evolution. Total 32 NS1 nucleotide sequences of Influenza A virus H5N1 strain varied from 831 to 875 bp were used to construct the phylogeny and nine major clades were obtained. The computational tool was used to model the RNA secondary structure of nine different strains of Influenza A virus. The thermodynamic free energy ranges between -222.90 to-251.10 Kcal/mol of the NS which may provide new insight to understand the evolutionary stability and pathogenesis of Influenza virus.