Журнал клинических и экспериментальных дерматологических исследований
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New Evaluation Method to Assess the Improvement of Glabellar Lines and Crow's Feet Lines with Onabotulinum Toxin A

Maurizio Cavallini and Marco Francesco Papagni

Background: Treatment with Onabotulinum toxin A for the improvement of glabellar lines and crow's feet represents one of the most requested and performed procedures in the field of aesthetic medicine. The efficacy of Onabotulinumtoxin A for the treatment of glabellar lines and crow's feet have been widely reported. Although, the assessment of the grade of efficacy is actually based on clinical evaluation scales by an healthcare professional, giving space to a wide interpretative subjectivity which depends on different factors including a personal experience and a subjective aesthetic judgment.
Objectives: This study aims to provide a digital evaluation tool in order to assess an objective measure of the degree of improvement for the areas treated with Onabotulinum toxin A, using a digital analysis of the images from the treated areas in order to exclude the subjective component during the evaluation.
Methods: A total of 20 women with moderate-to-severe CFL and GL (maximum contraction) were enrolled in the study. Each woman received a total of 44 U of Onabotulinum toxin A (20 U and 24 U for the treatment of glabellar lines and crow's feet, respectively). Images from the treated areas were collected using Antera 3D® device at baseline, 4 weeks and 4 months after treatment, at both rest and maximum muscles contraction.
Results: Improvements for both glabellar lines and crow's feet lines were detected with Digital Analysis of the Cutaneous Surface, further confirming the efficacy of Onabotulinum toxin A.
Conclusion: The digital evaluation tool proposed in this study is an objective and easy to use method for the assessment of glabellar lines and crow's feet lines improvements after the treatment with Onabotulinum toxin A.