Журнал клинической токсикологии
Открытый доступ

Абстрактный

Pharmacokinetic and Pharmacodynamic Drug-Drug Interaction and their Implication in Clinical Management

Gudisa Bereda

Drug interaction is a pharmacokinetic or pharmacodynamic consequence of medications on each distinctive, which can sequence, along with desiderated outcomes, in de-escalated effectiveness or escalated toxicity. “Drug-drug interaction” is delineated as the pharmacologic or clinical reaction to the administration of a drug conflation that is distinctive from the expected consequences of the dual medications when bestowed lone. Pharmacokinetic interactions happen when a medicine influences the absorption, distribution, metabolism, or excretion characteristics of disparate medicine PK DDIs happen as a sequence of a revamp in the vulnerability to a bestowed dose of lone medication when bestowed with distinctive. Medications that act as inducers or inhibitors of CYP450 enzymes in the enterocyte and hepatocyte perhaps revamp liability by revamping oral bioavailability. Pharmacodynamic interactions happen when dual medications that are taken coincidentally have either additive or revoking consequences on the body. The implicit for pharmacodynamic interactions should be thought-out for medications which contest with each distinctive at the pharmacological target and/or have analogous or combating pharmacodynamic (therapeutic or adverse) consequences.