Органическая химия: текущие исследования

Органическая химия: текущие исследования
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ISSN: 2161-0401

Абстрактный

Синтез, характеристика и биологическая оценка производных хиназолина как новых антимикробных агентов

Прабхакар В., Судхакар Б.К., Равиндранат Л.К., Латха Дж., Венкатешварлу Б.

A novel series of Quinazolines were synthesised by cyclisation reaction of Anthranilic acid with urea to get 2,4 di hydroxy quinazoline (2) intermediate, which were further treated with POCl3 to get 2,4 di chloro quinazoline (3), which was treated with Thio-morpholine (4) for 3 hrs to get compounds (5), which are reacted with aqueous ammonia to get compound(6), which was further reacts with different boronic acids 7(a-j) by using Chan-Lam coupling reaction conditions to get Target Novel Quinazoline derivatives (8a-8j). The structures of new compounds were confirmed by IR and 1H NMR and 13C NMR spectral data. Anti-bacterial and anti-fungal activities were evaluated and compared with the standard drugs, compounds 8i, 8d, 8h, 8g exhibited promising anti-microbial and anti-fungal activity compared to standard drugs.

Отказ от ответственности: Этот тезис был переведен с использованием инструментов искусственного интеллекта и еще не прошел рецензирование или проверку.
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