Журнал гликомики и липидомики
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Alterations in Lipoprotein Liposomes in Postmenopausal Women with Osteoporosis

Wei-Chun Chang

Osteoporosis is considered as an aging disease that affects the quality of life. Menopause is an important risk factor for
osteoporosis in women because of systemic alterations in metabolism. The changes in the levels of Total Cholesterol (TC),
Triglyceride (TG), and lipoproteins in blood are postulated to be associated with osteoporosis. The current study examined
systemic lipid profiles in post-menopausal women with and without osteoporosis. BMI (Body Mass Index) and levels of total
cholesterol and LDL (Low-Density Lipoprotein) were found to be lower in those with osteoporosis. There was no significant
difference in the levels of TG and HDL (High-Density Lipoprotein) among the study subjects. With high throughput lipid
profiling technology, the lipidomes of LDL and HDL in 205 postmenopausal women were determined. The LDL lipidomes
of patients with osteoporosis showed reduced levels of ceramide, decreased number of hydroxyl groups, and increased number
of double bonds, compared to normal individuals. For HDL lipidomes the levels of Lyso Phosphatidyl Ethanolamine (LPE)
were increased, and the number of double bonds was decreased in patients with osteoporosis. These results suggest a change
in systemic lipid metabolism in post-menopausal women with osteoporosis.