Анестезия и клинические исследования
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Brain Co-oximetry: An Useful Non-Invassive Parameter Adjuvant to Standard Perfusion Parameters in Septic Shock

Debdipta Das*, Koel Mitra, Sabyasachi Das

Background and aim: Standard monitoring for tissue perfusion includes mixed venous saturation (CvSO₂), blood lactate. Cerebral oximetry (CrSO₂) non-invasively observes trends in cerebral saturation and it can be used as adjuvant to standard monitoring. The aim of the study is to evaluate septic shock mortality and patient outcome.

Methods: In this study 40 patients were entailed with septic shock at ICU for study period of 10 months. CrSO₂ was monitored using “MASIMO O₃ Regional Oximetry”. Patients were monitored with CrSO₂, CvSO₂, blood lactate, mean arterial pressure (MAP), arterial oxygen saturation (SaO₂) 6 hourly for 72 hours. Patients with history of cerebrovascular diseases and neurological deficits were excluded from study. IBM SPSS Statistics, Version 24.0. software was used and independent t test, paired t test, Pearson coefficient (r) etc. parameter values were analyzed.

Results: There is significant negative correlation after six hours from admission was noticed between CrSO₂ and lactic acid (r=-0.749 to -0.956). Significant positive correlation was noticed between CrSO₂ and CvSO₂ (r=0.904 to 0.993). In addition, significant positive correlation was also found between CrSO₂ and mean arterial pressure (r=0.957 to 0.993) and SaO₂ (r=0.864 to 0.988). Significant difference was also detected between the value of CrSO₂ in the survivors (29 patients) and the non-survivors (11 patients) after 72 hours from admission.

Conclusion: CrSO₂ could be parameters in patients with shock and it could have a prognostic value in mortality prediction and clinical outcome.