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Chronic Interstitial Nephritis Induced by Long-Term Topical Application of Hair Dye

Xian Chen, Youming Peng, Hong Liu, Danyi Yang, Liyu He, Xiaofei Peng and Fuyou Liu

We provide a patient, habitually used a hair dye contained P-araphenylenediamine once every month for almost six years, who presents elevated creatinine and proteinuria and renal interstitial fibrosis by renal biopsy. Hair dye is widely used all over the world. There have been some literatures about hair dye induced acute kidney injury, but few about the topical application of it can induce chronic interstitial fibrosis. In view of the persistent usage of small dosage of hair dye can cause chronic kidney disease, it is indeed necessary for people to pay attention to the side effect of hair dye.