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COVID-19 Associated Multisystem Inflammatory Syndrome with Skin Lesions after Induction in Acute Myeloid Leukemia in a Pediatric Patient

Fernanda de Oliveira Mota

Severe SARS-CoV-2 infections in pediatrics are rare and usually presented as Multisystem Inflammatory Syndrome in Children (MIS-C). There are few descriptions about pediatric oncology patients. We describe a case of 5-year-old male with Acute Myeloid Leukemia (AML).

He presented febrile neutropenia with skin lesions and progressive clinical worsening. He had positive RT-PCR test for SARS-CoV-2 and criteria for MIS-C. He received methylprednisolone, immunoglobulin and granulocyte colony stimulating factor. Anti-interleukin 6 was administrated due to severe lung disease and refractory to treatment, presenting response and slow clinical recovery. Chemotherapy was restarted, he didn’t present relapse during treatment and has no sequelae of COVID-19. Severe SARS-CoV-2 infections in pediatrics are rare and presented as Multisystem Inflammatory Syndrome in Children (MIS-C). There are few descriptions about pediatric oncology patients. We describe an Acute Myeloid Leukemia (AML) patient who presented COVID-19 complicated by MIS-C. He had slow clinical recovery and was able to resume AML treatment.