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COVID-19 is a Contributing Risk Factor for Development of DKA in Type-I DM: A Cross Sectional Study

Noura M. El Bakry1*, Yosra S. Fadl1 , Ayat M.Mohamed2

Background: Viral infections trigger type 1 diabetes (T1D) in susceptible children, and may increase incidence of T1D and/or diabetic ketoacidosis (DKA) during the COVID-19 pandemic. We aimed to describe the frequency of diabetic ketoacidosis in children and to determine if COVID contribute to the risk of diabetic ketoacidosis.

Objective: To study the incidence of DKA due to new-onset T1D during the COVID-19 pandemic, and whether SARS-CoV-2 infection is a triggering factor for the development of DKA in T1D in Minia university hospital,Egypt.

Methods: This retrospective cohort study of children admitted to PICU and inpatient wards due to new-onset T1D or due to DKA and diagnosed as have positive COVID-19 in Mina University Hospital from 1 April to 31 October 2021. We compared the incidence, number and characteristics of children with newly diagnosed T1D and DKA during the pandemic periods.

Results: An increase in the number of children with newly diagnosed type 1 diabetes (T1D) has been reported during the COVID-19 pandemic and more children with new-onset T1D now present with severe diabetic ketoacidosis (DKA).

Conclusion: COVID contribute to the risk of diabetic ketoacidosis and new onset T1D among children.