Журнал гликомики и липидомики
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Distorted fatty acid metabolism and metabolic syndrome

Mahabaleshwar Hegde

Metabolic Syndrome, is a collection of risk factors that increases the chances of developing excessive body fat, heart disease, stroke and diabetes and it is primarily the result of recent abrupt dietary life style changes, more particularly distorted fatty acid intake. Our prehistoric food consisted of 1:1 ratio of omega-6 to omega-3 fatty acid. But today our diet has skewed ratio of 20-40:1. Both linoleic acid omega-6 and alphalinolenic acid omega-3 fatty acids are essential fatty acids. Excessive omega-6 and paucity of omega-3 fatty acid is almost a global phenomenon. Obesity is a worldwide epidemic responsible for 5% of global mortality. The risks of developing other key metabolic disorders like diabetes, hypertension and cardiovascular diseases (CVDs) are increased by obesity, causing a great public health concern.