Эндокринология и метаболический синдром
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Effect of an Exercise Program, on Hemodynamic, Metabolic and Inflammatory Markers in Obese Mexican Adolescents

Benigno Linares-Segovia, Juan Manuel Guizar-Mendoza, Norma Amador-Licona, Gloria Barbosa-Sabanero and Juan Manuel Malacara

Background: Obesity prevalence has increased in Mexican adolescents. This disease is associated with a chronic inflammatory response, which has been proposed to have an important role in cardiovascular disease. The aim of this study was to evaluate the short term effect of a moderate-intensity physical activity program on hemodynamic, metabolic, and inflammatory markers in obese adolescents. Findings: We performed a longitudinal study in 43 healthy obese adolescents (26 female and 17 male). The study was conducted at the Mexican Institute of Social Security in Leon, Mexico. Subjects were submitted to aerobic exercise training during 90 minutes for 16 weeks, 5 days per week. Before and after the intervention program, hemodynamic, metabolic and inflammatory parameters were measured. Body weight was reduced by 4%. Blood pressure, insulin, insulin resistance, C reactive protein, interleukine 6, intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 serum levels significantly decreased independently of gender while adiponectin levels increased. In the multiple regression analysis, the increase in adiponectin levels and the decrease in body mass index were related to systolic blood pressure levels (R2= 0.26; p=0.001), while final maximum O2 consumption rate and final systolic blood pressure levels were related to decrease in C reactive protein levels (R2= 0.79; p=0.0001). Conclusions: A moderate-intensive exercise for 90 minutes a day at short term significantly diminished adiposity, hemodynamic, metabolic, and inflammatory markers in obese adolescents.