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Effect of Genetic Polymorphisms in CD14 and TLR4 on Cardiomyopathy

Avinash Bardiaa, Siddhratha Rout, Sandeep Kumar Vishwakarma, Chandrakala Lakki Reddy, Shaik Iqbal Ahmed, Pratibha Nallari and Aleem A Khan

Background: We investigated polymorphisms of immune related genes (CD14 and TLR4) and explore the associations of these variants and risk of CM.

Method: We detected SNPs of CD14 (-159C>T) and TLR4 (299 A>G) using the polymerase chain reaction (PCR) with peripheral blood samples from 141 patients with CM and 198 healthy people, further analyzing their relations with the risk of CM.

Result: The CT genotype of CD14 gene was found to be associated with CM and 1.84 folds increased risk to CM when compared to CC genotype (OR 1.84, 95% CI 1.18–2.88, P=0.0051). Heterozygotes (AG) of TLR4 gene were found to be predominant in the CM group when compared to controls (50.4%, 38.4% respectively, P=0.0081) with 1.79 folds increased risk for CM, which was statistically significant (OR 3.79, 95% CI 1.15–2.80, P=0.0081).

Conclusion: Polymorphism in CD14 and TLR4 gene is associated with an increased risk of CM. The combined effects of polymorphisms within innate immune genes of CD14 and TLR14 may contribute to a high risk of CM.