Гинекология и акушерство

Гинекология и акушерство
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ISSN: 2161-0932


Effects of Myo-inositol, D-chiro-inositol and Glucomannan in PCOS Women: Prospective Observational Multicentric Cohort Study

Leo V De, Guida M, Cianci A, Cappelli V, Bastianelli C, Farris M, Capozzi A and Lello S

Objective: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrinopathies of the reproductive age in women. PCOS is an endocrine-metabolic disorder characterized by insulin resistance. Aim of the study was to evaluate the efficacy of natural substances such as inositol and glucomannan, and their combination in reducing glucose levels and improving insulin sensitivity in PCOS patients.

Methods: 100 PCOS insulin-resistant women were enrolled for the administration of myo-inositol 1,75 g, D-chiroinositol 0,25 g, and glucomannan 4 g a day for 90 days.

Plasma levels of glucose and insulin, BMI, menstrual cycles, Ferriman Gallwey score, and acne were evaluated before and after treatment.

Results: There was a significative reduction of glucose, insulin, acne and Ferriman Gallwey score.

Conclusion: Present results show that the association-inositol glucomannan may represent a good therapeutic strategy in the treatment of PCOS women with insulin resistance.