Иммунотерапия: открытый доступ
Открытый доступ

Абстрактный

ATG5 Promotes Head and Neck Squamous Cell Carcinoma by Regulating Translation and Cell Cycle

Haidong Fan, Junquan Weng, Huijuan Liu, Hui Zhang, Su Tang

Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is the most prevalent malignant tumor of the maxillofacial area. ARGs (Autophagy-Related Genes) are involved in the cell cycle and translation, which will fuel carcinogenesis.

Material and methods: TCGA data for ARGs in HNSCC were analyzed. The functional role of the ATG5 in HNSCC was investigated through ATG5 knockdown cell lines.

Results: According to the TCGA data, ATG5 was shown to be an adverse prognostic marker. Regardless of tumor stage, grade, or clinical characteristics, HNSCC patients with high ATG5 expression had a poorer survival rate. ATG5 knockdown suppressed the malignant features of HNSCC cell lines. The mechanism study demonstrated ATG5 knockdown could prevent the malignant phenotype of HNSCC by reversing the cell cycle and translation. One of the systems influencing cell cycle control in ATG5-dependent ways might include HDAC2, TTK, and CDK1. MRPL18, MRPL13, and MRPS14 might all be implicated in ATG5-dependent translation regulation.

Discussion and conclusion: The current research suggests that ATG5 is a key player in cell cycle and translation regulation, as well as poor prognosis in HNSCC.