Журнал клеточной науки и терапии
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Excessive Adiposity an Established Risk Factor for Metabolic Diseases

Rui Yamaguchi and Yasuo Yamaguchi

Excess adiposity is an established risk factor for metabolic disease and visceral adipose tissue plays a major role in the low-grade inflammatory state associated with obesity. Chemokines play an important role in leukocyte trafficking and circulating chemokine levels are increased by inflammatory processes, including obesityrelated diseases. Chemokines are key factors in innate and adaptive immunity. Human adipocytes were derived from cryopreserved omental preadipocytes of subjects with a body mass index (BMI) <30 kg/m² or >30 kg/m².