Анестезия и клинические исследования
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ISSN: 2155-6148
ISSN: 2155-6148
Diana Christine Lalenoh and Dewi Yulianti Bisri
Since the Glasgow Coma Scale was developed 40 years ago it has been accepted throughout the world as a method for assessing impaired consciousness.
Fourty moderate TBI patients were simple randomly divided into 2 groups: group A take normal saline infusion without lidocaine as control group (N=20), and group B take normal saline with lidocaine at rate 1 mg/kg/BW infusion as treated groups (N=20). Serum samples were collected at before induction and 2 hours after giving infusion treatment to measure serum IL-6 and PLA2 level, and lidocaine serum concentration. GCS were measured before induction and after 24 hours surgery. Data were analyzed using analytic statistic with paired t test to measure serum IL-6, PLA2, & lidocaine serum level before induction and after 2 hours. The correlation of serum IL-6, PLA2 and GCS was measure with Separman correlation. A P value less than 0.05 were considered significant.
The result are both serum IL-6 and PLA2 levels were significantly lower in saline with lidocain infusion group (p<0.005) with Mann Whitney and Dependent t test statistically analyses. The lower serum IL-6 and PLA2 levels, the higher GCS value. GCS measurement was significantly higher in lidocaine infusion group (p<0.05) with dependent t test. The decrese in serum IL-6 and PLA2 was correlated with the dosage of lidocaine. Medium doses of lidocaine achieved the optimum decreases in the serum IL 6 and PLA2 level. Therefore, inhibition of the composition and secretion of IL-6 and PLA2 levels by Lidocaine might be one of the mechanisms involved in decreasing inflammatory reaction and cellular damage in brain cells, and may be responsible for the neuroprotective effect after TBI. Glasgow Coma Scale was improving after infusion with lidocaine 1 mg/ kg/ hr during traumatic brain injury surgery by decreasing IL-6 and PLA2 plasm.