Журнал прикладной фармации
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IN VITRO EVALUATION OF ANTIBACTERIAL, ANTIFUNGAL AND PHYTOTOXICITY ACTIVITY OF DIFFERENT EXTRACTS OF LEAVES OF KALANCHOE PINNATA

Yousaf Kamal, Bashir Ahmad Ch, Muhammad Uzair, Nadeem Irshad, Muhammad Yaseen, Iftikhar Hussain

Background: The emergence of drug resistance in pathogens as well as appearance of undesirable side effects of certain antibiotics has led to the discovery of new antibacterial agents particularly from medicinal plants. Objective: In this study, we have found the in vitro antibacterial, antifungal and phytotoxicity activity of dichloromethane and methanol extract of leaves of kalanchoe pinnata (lam) pers. Method:The antibacterial activity of the plant leaves evaluated against microbial flora Bacillus subtilis (PTCC 1207), Bacillus cereus (PTCC 1247), Staphylococcus epidermidis (PTCC 1114) and Escherichia coli (PTCC 1047) antifungal activity against Epidermophyton floccosum, Trichophytum mentogrophytes, T.rubrum, T.simii, T.scheonleinii, Microsporum canis, Pseudallescheria boydii, Candida albicans by using disc diffusion method etc. Results: Result showed that the tested extracts posses mild or non-significant antimicrobial and antifungal activities. Amoxicillin 10mg/ml was used as standard compound. The leaves extract of dichloromethane and methanol showed less zone inhibition compared than standard compound. Conclusion: It could be suggested that the dichloromethane and methanol extracts of Kalanchoe pinnata leaves possess non-significant antibacterial and anti-fungal activities