Журнал клеточной науки и терапии
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Intestinal Dysbiosis Induced Chronic Inflammation that Risk up Oxalate Nephropathy

Shruti Gupta, Shamsher Singh Kanwar*

Oxalate nephropathy is a devastating renal disease with poor prognosis which can often cause a gradual kidney dysfunction with a significant risk of End Stage Renal Disease (ESRD). Typically associated with chronic interstitial nephritis or fibrosis as well as acute kidney injury, oxalate nephropathy is characterized by deposition of Calcium oxalate (CaOx) crystals in kidney tubules. The gut plays a significant role in oxalate handling. Dysbiosis induced oxidative stress, systemic inflammation and lack of oxalate degrading bacteria remarkably contributes to the oxalate nephropathy. Here we propose a microbiome-centric theory of oxalate nephropathy where initial adaptive changes in gut microbiome embark chronic inflammation in later stage, leading to Chronic Kidney Disease (CKD)-related complication such as oxalate nephropathy.