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Ionization Techniques in Mass Spectrometry: A Review

Sharad Medhe

Mass Spectrometry- It is an analytical technique that generates charged particles in the form of ions from the substance to be analysed to measure its mass to charge ratio. Ion Source plays an important role for generation of charged ions which further travels through analyser and ends at detector. The production of intact molecular ions can be achieved under adequate experimental conditions, with minimal fragmentation known as soft ionization method. Neutral species either loss or gain of charge to generates ions. This paper covers an information about various type of mass ion Source (Electron impact, Chemical ionization and field ionization, Desorption-Field desorption, Electro spray ionization, matrix assisted desorption ionization, Plasma desorption) are in use for mass spectroscopy. Ions get affected by change in electrical, magnetic and radiofrequency effect as they containing either positive or negative charges this leads to better resolution of ions.