Журнал клинических и экспериментальных дерматологических исследований
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Multiforme Erythema, In Child, After Repeated Herpes Simplex Infections - Case Presentation

Ymran Blyta, Kocinaj A, Ferizi M, Gerqari A and Ahmeti N

Background: Erythema multiforme (EM) is a distinctive hypersensitivity syndrome characterized by skin and mucous membrane lesions and in its more severe forms, visceral involvement. The condition varies from a mild, selflimited rash to a severe, life-threatening form. The most common predisposing infection is Herpes simplex, but bacterial infections, fungal diseases and drugs are also implicated. The literature cites that half of children with the rash have recent herpes labialis.

Methods: This is a case report of a 12 years old male patient. The patient had herpes simplex labialis by admission in our clinic. The patient had recurrent infection from 6 years of age with clinical appearance two times per year. In both situations, it was followed by erythema multiforme with one week latter onset. This is the second time that he developed acutely typical target skin lesions, on the face and extensor surfaces of hands. The lesions were distributed symmetrically and spreading centrally.

Conclusions: Although the etiology of EM is still often unknown, infections with herpes simplex virus have been implicated as common predisposing a possible precipitating factor. This case illustrates the association of the occurrence of EM with a herpes simplex virus (HSV) infection and antiviral drugs are necessary to given for future prophylaxis of recurrence of both clinical features.