Журнал клинической токсикологии
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Синдром полиорганной недостаточности, осложняющий рефрактерный кардиогенный шок, вызванный передозировкой метадона и леченный с помощью экстракорпоральной поддержки жизнедеятельности (ECLS)

Антуан Бертон, Жюльен Имбо, Рубен Конкальвес, Бенжамен Репюссо, Александр Уаттара, ЧЮ Бордо

We describe a patient presenting multiple organ dysfunction syndromes complicating a refractory cardiogenic shock caused by massive methadone intoxication. Neither ECG changes nor echocardiography abnormalities suggesting the diagnosis of Takotsubo syndrome could be observed at the admission. The QT interval was also normal. An Extracorporeal Life Support (ECLS) was rapidly implanted in bridge to decision. The myocardial failure was fully reversible after 10 days. This case is the first to report multiple organ dysfunction syndromes complicating refractory cardiogenic shock related to methadone poisoning requiring ECLS. It emphasizes that a diagnosis must be imperatively suspected in patients with history of drug abuse and for whom methadone is rendered available even in absence of typical ECG and/or echocardiography changes.