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ncRNAs-mediated Upregulation of GTSE1 is Involved in the Poor Prognosis and Tumor Immune Infiltration of Clear Cell Renal Cell Carcinoma

Kuang Xiayu, Cai Guogang, LI Canxuan*

Aims: Examine GTSE1 expression and function in renal clear cell carcinoma, as well as the nc-RNA that is upstream of GTSE1 .

Methods: The Cancer Genome Atlas (TCGA) provided clinical and RNA-seq data for ccRCC patients, and the expression of GTSE1 , its connection with clinical data, prognosis and tumor immune infiltration, and prediction of upstream noncoding RNAs (nc-RNAs) of GESE1 were analyzed using R language and public tumor databases.

Results: In ccRCC, GTSE1 is highly expressed and is linked to a high clinical stage and a poor prognosis. In ccRCC, the PVT1/has-mir-23b-3p/ GTSE1 axis has been identified as the most likely upstream ncRNA related route of GTSE1 . Furthermore, GTSE1 expression was linked to tumor immune cell infiltration, immune cell biomarker expression, and immunological checkpoint expression.

Conclusion: Upregulation of GTSE1 by ncRNA is linked to poor prognosis and ccRCC tumor immune infiltration. GTSE1 has the potential to be a useful predictive biomarker as well as a therapeutic target.