Журнал клинической токсикологии
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Observations on Mitragynine Use

Amadeo Pesce

Mitragynine is the principal alkaloid found in the leaves of kratom (Mitragyna speciosa), a tropical tree indigenous to Southeast Asia Thailand, Malaysia, and Papua New Guinea. Mitragynine has become a drug of interest because of its increased use among substance abusers and patients seeking pain relief. Often the use of this drug is not disclosed by patients testing for the drug is possible because of recent advances in laboratories using LC-MS/MS and/or LC-TOF and the availability of appropriate standards. We observed the median amount of drug in urine to be 88 ng/mL we documented about a three=fold increase in the use of this drug over the past five years in our population of pain and substance abuse patients undergoing urine drug monitoring.