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Optimized Protocol is the Key for Clinical Use of Stem Cell Therapy in Stroke

Mohammad Hossein Khorraminejad Shirazi and Seyed Mojtaba Hosseini

Stroke is the second cause of mortality in industrial countries after ischemic heart disease. Ischemic stroke results from an artery occlusion and leads to oxygen and glucose shortage in brain. Cerebral ischemia results in inflammation and oxidative stress leading to neuronal loss and brain damage. To these days, rt-PA is the only approved drug for stroke; however, increasing the risk of bleeding and golden time limitation are the problems associated with rt-PA.