Журнал клеточной науки и терапии
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Overview of Radiation-Induced Crosslinking of Macromolecules to Synthesize Nanogels for Biomedical Applications

Aiysha Ashfaq, Piotr Ulanski*, Mohamad Al-Sheikhly*

Nanogels (NGs) have kindled great interest in a wide variety of biomedical applications over the past few decades. This has given rise to numerous methods to synthesize these globules but often times the use of toxic additives decrease the biocompatibility of the synthesized gels. The method presented in this review uses high-energy ionizing radiation to induce the crosslinking of macromolecules in aqueous solution. This method effectively increases the biocompatibility of the NGs by eliminating the need of toxic monomers, chemical cross linkers, initiators etc. This mini-review will provide a brief discussion of the theory and methodology behind this method. Nanogels applications as related to cell therapy will also be explored.