Педиатрия и терапия
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Partial Exchange Transfusion for Hyperviscosity and Necrotizing Enterocolitis after Complication of Intravenous Immunoglobulin in a Late Preterm Infant: Case Report and Review of the Literature

A Ulas Tugcu *,Ayse Ecevit ,Aslihan Abbasoglu ,Namik Ozbek ,Aylin Tarcan

Thrombocytopenia is not rare haematologic finding in the sick newborn infants, it occurs frequently in patients who were admitted to newborn intensive care units. Use of intravenous immunoglobulin (IVIG) in newborn infants has brought some amelioration to primary and secondary immune deficiencies, haemolytic disease of newborn, autoimmune thrombocytopenias and sepsis. There have been reports of thrombotic events in especially in adults and children after usage of high dose IVIG. However some unexpected adverse effects started to be reported by the increasing usage of IVIG. In this case we described a late preterm infant with necrotizing enterocolitis after IVIG treatment of neonatal isoimmune thrombocytopenia. After IVIG treatment, necrotizing enterocolitis began to occur and high blood viscosity was detected. We performed partially exchange transfusion. Thrombocyte numbers did not increase but significant improvement of clinical status occurred.