Журнал гематологии и тромбоэмболических заболеваний
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Pathogenesis, Prognosis and Management of Deep Vein Thrombosis

Reza Pahlavi

The development of a blood clot (partial or whole blockage) in venous or arterial blood arteries, which restricts the blood's normal flow and causes clinical sequelae, is referred to as thrombosis. Blood cells (including platelets), plasma proteins, coagulation factors, inflammatory factors and cytokines, and the
endothelial lining of arteries and veins all work together to maintain a complex balance that permits blood to flow freely in
vessels. A thrombosis rather than a coagulopathy may be more likely to develop when there is an imbalance with this physiological function (increased risk of bleeding). Patients may experience elevated thrombosis and concomitant bleeding risk under specific clinical conditions (e.g., disseminated intravascular Coagulopathy-DIC, or in patients with underlying malignancy who develop a coagulopathy). The diagnosis and treatment of thrombosis are therefore complicated. Any organ system might experience them, and depending on underlying comorbidities and the presence (or absence) of triggering stimuli, their clinical presentation can vary. Management choices can be influenced by a variety of circumstances, such as whether the condition is venous or arterial, acute or chronic, the first or subsequent episode, family history, risk factor assessment, and hemodynamic stability.