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Potential Approach of Hepatitis B by Inhibiting MDSC to Obtain Control of the Immune System

Cosmin Constantin Oprea

Purpose of Review: Hepatitis B virus infection and the immune response in babies and adults.

Findings: The presence of myeloid-derived suppressor cells (MDSCs) in new-borns makes Hepatitis B to become chronic over years with both antigens present in the blood, HBs and HBe, the immune system not being able to recognize the infection in the first years of life. The expansion of myeloid-derived suppressor cells (MDSCs) allows the immune system to maintain the infection with Hepatitis B, although the patient reaches adult age, because myeloidderived suppressor cells (MDSCs) are responsible for the disfunction of the immune system and not the virus itself. Our goal is to show what is maintaining T cell exhaustion in hepatitis B, why this is happening and what is responsible for this.

MDSC is responsible for chronic Hepatitis B infection. The expansion of MDSC is the format in which hepatitis B manage to escape the immune system’s response. MDSC cells have the ability to interact with these signals generated by common progenitor lymphoid cells and in this way the immune system cannot exercise its function.