Журнал клинических и экспериментальных дерматологических исследований
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Primary Cutaneous CD4+ Small/Medium T-cell Lymphoproliferative Disease: A Case Report

Marzouq Amarin, Ahmad Mansour, Ali Anaswah, Raed Al-Taher and Mohammad Al-Qaisi

Primary cutaneous lymphoma is a heterogeneous group of diseases. Primary cutaneous CD4+ small/medium Tcell lymphoma (CD4+ SMTCL) is one of the rare subtypes; representing only 2-3% of all cutaneous lymphomas. It was recently described as lymphoproliferative disorder because of its indolent clinical behavior and many similarities with cutaneous pseudolymphoma. This disease is a provisional entity according to latest World Health Organization (WHO) classification of hematolymphoid tumors. CD4+ SMTCL has a n excellent 5-year survival of 60-85%. CD4+ SMTCL usually present with a solitary skin lesion of the head and neck region, and most of reported cases were treated with local managements only. The common clinical presentations and histological features are still not well understood, and no optimal therapy is established. We report a case of primary cutaneous CD4+ small/medium Tcell lymphoma, our patient presented with a facial skin lesion that was treated with excision only.