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Progenitor Endothelial Cell Dysfunction in Heart Failure: Clinical Implication and Therapeutic Target?

Alexander E Berezin

Chronic heart failure (HF) is a leading clinical and public problem affected higher risk of morbidity and mortality in different population. There is emerging evidence regarding that the epigenetic regulation may have a clue in the pathogenesis of HF. Epigenetic modifications including DNA methylation, ATP-dependent chromatin remodeling, histone modifications, and microRNA-related mechanisms, may involve in the endothelium reparation and injury through mobbing and differentiation of endothelial progenitor cell (EPCs). Recent clinical studies have shown that cardiovascular risk may contribute to epigenetic regulation of structure and functionality of EPCs leading to EPCs’ dysfunction and worsening of endothelium repair. The short commentary is represented current available evidence regarding an implication of epigenetic modifications in development of EPC dysfunction and its importance for use as a target for HF treatment.