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Progression of Nodular Lymphocyte-Predominant Hodgkin’s Lymphoma to a High-Grade Lymphoma

Riley JM, Jenrette JM, Gordon L, Milligan L, Zauls AJ and Stuart RK

Nodular lymphocyte-predominant Hodgkin’s lymphoma (NLPHL) is a rare subtype of Hodgkin’s lymphoma characterized by a nodular proliferation of large neoplastic B cells that are CD15 and CD30 negative. Although this neoplasm develops slowly and has a favorable prognosis with Stage I or II disease, it has a high rate of recurrence and patients tend to have repeated relapses [1]. Increasingly, reports have shown that a small percentage of patients with NLPHL may transform to a more aggressive lymphoma concurrently or many years later. This case highlights a 58 year-old man who developed NLPHL at age 33 and progressed to a high-grade malignant lymphoma 25 years later. The purpose of this report is to share this patient’s unusual clinical course and provide a pertinent literature review of NLPHL.