Журнал клинической токсикологии
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ISSN: 2161-0495
ISSN: 2161-0495
Friday E. Uboh, Saviour U. Ufot, Uduak O. Luke, Godwin O. Igile and Chinelo M. Ozojie
Effect of vitamins C (vitamin C) and E (vitamin E) on nitrocellulose thinner (NCT)-induced nephrotoxicity in male rats was assessed. Six groups of six rats each, were orally administered 0.5 ml distilled water, 0.5 ml soybean oil, 40.0 mg NCT/kg bwt, 40.0 mg NCT/kg bwt+200 mg vitamin C/kg bwt, 40.0 mg NCT/kg bwt+200 IU vitamin E/kg bwt, and 40.0 mg NCT/kg bwt+200 IU vitamin E+200 mg vitamin C/kg bwt, respectively, for 30 days. The animals were sacrificed, 24 hours after last experimental treatments, blood and kidney tissues were collected for analyses of indicators of nephrotoxicity using standard methods. The results showed a significant (p<0.05) increase in serum creatinine (sCr), urea, uric acid, K+, HCO3 - and Cl- and decrease in serum Na+ levels, as well as severe renal histological changes in rats exposed to NCT only, compared to the values obtained for the control groups receiving only distilled water and soybeans oil, respectively. No significant (p>0.05) difference was recorded for these parameters in rats receiving soybean oil, compared with control rats receiving distilled water. These results indicated that exposure to NCT induced nephrotoxicity in rats. It was also observed that administration of vitamin C and vitamin E, in combination and singly, to rats exposed to NCT produced relatively normal renal histological status, and levels of the assayed serum nephrotoxicity indicators within the control range; suggesting vitamin C and vitamin E to be potent in preventing NCT-induced nephrotoxicity in rats. However, comparative percentage decreases (CPD) in sCr, uric acid, K+ and HCO3 - indicated that combined vitamin C and vitamin E administration produced a higher protective potency than single administration; and that vitamin C produced a higher potency than vitamin E against NCT-induced nephrotoxicity.