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Regression: An Atypical Presentation of Lupus Cerebritis

Precious Macauley

Neurologic manifestations in systemic lupus erythematosus (SLE) ranges broadly from more common manifestations such as headaches, mood disorders, cognitive dysfunction, cerebrovascular disease to rarer ones including Guillan Barre syndrome, myasthenia gravis and autonomic dysfunction.
We present a case of a 39 year old Hispanic female with newly diagnosed SLE who presents with childlike behaviour. She had serologic evidence of lupus activity and all infectious etiology was ruled out. She had a protracted course but symptoms were eventually controlled with intravenous steroids, cyclophosphamide, rituximab and intravenous immunoglobulin.
This case is reported because regression has not previously been documented as one of the possible manifestations of neuropsychiatric SLE.