Журнал клинических и экспериментальных дерматологических исследований
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Rejuvenation of Frontal and Periorbital with Hyaluronan Hybrid Cooperative Complex (HCC): A Novel Technique

Juliana Schinzari Palo, Gladstone Eustaquio de Lima Faria, Maria Clara Lopes Nobre, Ana Carolina Henriques Ribeiro Machado, Ricardo Frota Boggio

Background: Hybrid Cooperative Complex (HCC) is a novel molecule, launched worldwide in 2016, which contains ultrapure high and low molecular weight hyaluronic acid stabilized in a thermal process and without chemical additives, and it is indicated for tissue remodeling and improvement of sagging skin. It is proved that HCC can stimulate the production of elastin and collagen by keratinocytes and fibroblasts, differentiation of steam cells into adipocytes, and accelerate the wound healing process. It is currently described for treating the mid and lower third of the face, but not the upper third. Its great integration capacity and uniform diffusion are favorable characteristics for the forehead and periorbital region, with tissues frequently adhered to the underlying musculature.

Objective: To evaluate the effectiveness and safety of HCC in the upper third of the face and to describe a novel technique of application.

Methods: Nine subjects received HCC treatment in the forehead and periorbital regions, two applications with a 4- week interval, with a 22 gauge microcannula technique, under anesthesia. Photographs with Vectra^® Software were taken and a non-involved doctor compared the photographs taken and used de Global Aesthetic Improvement Scale (GAIS) score to classify. Subjects were asked in the end of study about perception of improveness in luminosity and hydration of forehead and periorbital skin. This is the first study involving the treatment of the upper third of the face with HCC.

Results: The GAIS score was 2 after the 9th week; 56% of the subjects noticed improvement of hydration, and 78% noticed improvement of luminosity. No important adverse events happened. Seven out of nine of the patients would recommend the treatment and would repeat it.

Conclusion: HCC is a safe and effective treatment option for the upper third of the face. Further studies should be conducted to understand the long-term performance of the product.