Анестезия и клинические исследования
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Risk of Adverse Effects Using Antibiotic Prophylaxis in Ambulatory Cystoscopy: A Systematic Review

Herney Andrés García-Perdomo, Eladio Jiménez-Mejías and Hugo López-Ramos

Objective: to determine incidence of adverse effects related to antibiotic prophylaxis compared to other interventions in patients who undergo cystoscopy with sterile urine. Methods: Search strategy (January 1980-January 2014) in Medline via PubMed, CENTRAL, and EMBASE. Additionally, we searched databases for registered trials and conference abstracts, as well as reference lists of systematic reviews and included studies. Two published randomized placebo-controlled trials (January 1, 1980 and January 31, 2014) were included in qualitative analysis with no language restrictions. Two independent reviewers collected Data. Risk of bias was evaluated with the Cochrane Collaboration recommendations. The primary outcome was incidence of adverse effects (AE).

Results: 2448 patients were found in the studies of García-Perdomo et al., and Jimenez-Cruz et al. The incidence of AE in one study was 0.7% in intervention group (nausea), no AE in control group or in the other study included. A meta-analysis was not performed.

Conclusions: There is a low incidence of adverse effects associated with antibiotic prophylaxis in cystoscopy besides we found inadequate conducting and report of this outcome in studies included.