Post mortem analyses in vultures across India and its neighboring countries traced diclofenac and its derivative compounds in their carcasses. Therefore, it is inferred that biomagnification of diclofenac from the consumed infected domestic animal carcasses contributes mortality by causing renal failure and hepatic damages in vultures. However, reports also indicate that both extrinsic environmental and intrinsic cellular causes might also be contributing factors. It offers a debate to confirm whether only diclofenac is the primary cause of vulture mortality versus their susceptibility to microbial pathogens, diseases or physiological conditions, such as oxidative stress due to diclofenac biomagnification. It is observed that natural disasters such as heavy cyclonic storm which affect arboreal life may be one of the major causes of the death of vultures in some parts of India. Therefore, extrinsic insults such as heavy cyclonic storms are believed to be also contributing factor to affect arboreal life including vultures in some other parts of the world. A perspective is made on the above facts as a cause of catastrophic mortality of vultures in India.