Анестезия и клинические исследования
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Role of Steroids in Prevention of Pain on Propofol Injection

Monu Yadav, Padmaja Durga and R. Gopinath

Background and objectives: Pain following intravenous injection of propofol continues to be an intriguing problem. None of the commonly used methods completely attenuate the pain. Inflammatory response to propofol contributes to the pain. Role of hydrocortisone in attenuating pain has not been evaluated. This study was conducted to compare the efficacy of lignocaine and hydrocortisone in attenuation of pain following intravenous injection of propofol.

Methods: A prospective randomized double-blind, placebo-controlled study was conducted on 72 adult patients belonging to ASA physical status I or II, scheduled to undergo elective surgery. They were randomly assigned into four groups of 18 each. Group NS, group LG, group HC10, and group HC25, received 2ml normal saline, 2ml 2% lignocaine, 10mg/2ml hydrocortisone and 25mg/2ml hydrocortisone respectively as pretreatment. Propofol was injected 30 sec later. A blinded researcher assessed the patient’s pain level using a four point verbal rating scale.

Results: The four groups were comparable in respect to patient’s characteristics. There was no significant difference of haemodynamics changes during propofol induction between all the groups. There was no statistically significant difference in the incidence of pain between patients who received hydrocortisone and the placebo group. The incidence of pain was significantly less in group LG than other 3 groups.

Conclusion: Use of intravenous low dose hydrocortisone pretreatment of the vein does not attenuate pain following propofol injection.