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Spermicidal Efficacy of Thevetia Peruviana Leaves by Modulating DNA Damage and Antioxidant Status

Chhanda Mallick, Prabir Mondal

Spermicidal agents from herbal sources are more effective and safer. Thevetia peruviana is an herb that has effective spermicidal activity by altering motility, viability of healthy human spermatozoa. Catalase and superoxide dismutaseT. peruviana activities were decreased but MDA levels elevated significantly in sperm cells after the 5 min treatment of hydromethanolic (2:3) extract of T. peruviana at 160 mg/ml dose. It also alters the sperm DNA integrity that is measured by comet assay.