Органическая химия: текущие исследования
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Синтез, характеристика и противоопухолевая оценка in vitro новых производных пиразоло[3,4-d]пиримидина

Ахмед М Эль-Морси, Мохамед С Эль-Сайед, Хамада С Абулхаир

A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The antitumor activity of this series against human breast adenocarcinoma cell line MCF7 was evaluated. Out of twenty new derivatives, ten were revealed mild to moderate activity compared with doxorubicin as a reference antitumor. Among this new series N-(2-chlorophenyl)-2-(3-(methylthio)-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide (13 a) was found the most active one with IC50 equal to µM.