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The Potential Safety of Deferring Percutaneous Coronary Intervention Based on Fractional Flow Reserve in The Ischemia-Induced Intermediate Lesions Defined by Intravascular Ultrasound

Jiang-Li Han, Ke Cao, Yong-Zhen Zhang, Ming Cui, Jie Niu, Gui-Song Wang, Fu-Chun Zhang, Lin Mi, Dan Zhu, Li-Jun Guo* and Wei Gao

It has been proved that it could achieve optimal clinical outcomes by using fractional flow reserve (FFR) to guide percutaneous coronary intervention (PCI). Many studies have reported some anatomic measurements such as minimal lumen area (MLA) by intravascular ultrasound (IVUS) is associated with FFR, but there were few data in Chinese. We assessed the optimal IVUS criteria for functional significant stenosis in Chinese and then evaluated the potential safety of deferring PCI according to FFR>0.80 in those IVUS defined ischemic lesions. A total of 125 intermediate lesions (30% to 70% diameter stenosis) from 101 patients were evaluated by both FFR and IVUS, and a 12 months follow up was made. The major adverse cardiac event (MACE) was defined as a combined endpoint of all cause death, non-fatal myocardial infarction (MI) and target vessel revascularization (TVR). IVUS-MLA showed a positive correlation with FFR (r=0.483, p