select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='16009' and ad.lang_id='3' and j.lang_id='3' and vi.lang_id='3'
ISSN: 2155-9554
Olga Martínez-Sáez, Eva Hermosa-Zarza, Alfredo Carrato and Reyes Ferreiro Monteagudo
We present the case of a patient undergoing chemotherapy with 5-Fluorouracil (5-FU), irinotecan and cetuximab, who presented polymorphous skin lesions with oral and genital mucosal involvement. The differential diagnosis included paraneoplastic pemphigus, a severe autoimmune disease associated with neoplasms. The histology can be variable with acantholysis or lichenoid dermatitis. The presence of circulating antibodies supports the diagnosis. In our case, the anatomopathological and immunological findings and the clinical improvement after the suspension of 5-FU confirmed that it was toxicoderma secondary to the latter.