Иммунотерапия: открытый доступ
Открытый доступ

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Transforming Growth Factor – Β1 and Pre-Eclampsia: Perspectives for Novel Therapeutic Modalities

Parveen Jahan, Goske Deepthi, Kamakshi Chaithri Ponnaluri and Komaravalli Prasanna Latha

Breakdown in the immunoregulatory mechanism as well as dysregulated angiogenesis are critical contributors to the obstetric disorder, Pre-eclampsia [PE]. The pleiotropic cytokine, Transforming Growth Factor-β1 [TGF-β1], with its immunosuppressive and angiogenic functions appears to be a promising candidate for prospective therapies in PE, as gleaned from a survey of candidate gene association and biochemical investigations. The current article endows with a background and gives inkling for the plausible therapeutic strategies for PE employing TGF-β1, given the veracity that proper curative procedures are not yet existent for this disorder.