Журнал лекарственного метаболизма и токсикологии
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White Rot Fungus (Pleurotus pulmonarius) Cultivated on Lead Contaminated Rice Straw Induced Haematotoxicity and Lead Accumulation in Liver and Kidney of Wistar Rats

Rhoda S. Onifade, Chibuisi G. Alimba, Clementina O. Adenipekun and Adekunle A. Bakare

White rot fungi (Pleurotus species) are edible mushrooms known for their ability to bioaccumulate contaminants including metals from the environment. There is scarcity of information on the toxic effects of the bioaccumulated metals on organisms at higher trophic levels. In this study, we investigated alterations in haematological indices and erythrocyte morphology and lead bioaccumulation potentials in liver and kidney of Wistar rats fed aqueous extract of Pleurotus pulmonarius cultivated on lead (0, 10, 100, 200, 500 and 1000 mg/L) contaminated rice straw substrate. After 8 weeks of cultivation, mushroom did not germinate in the 1000 mg/L Pb contaminated rice straw. 1 g of mushroom harvested from each of the remaining concentrations showed significant (p