Журнал протеомики и биоинформатики
Открытый доступ

Абстрактный

A Comprehensive Curated Reaction Map of Leptin Signaling Pathway

Vishalakshi Nanjappa, Rajesh Raju, Babylakshmi Muthusamy, Jyoti Sharma, Joji Kurian Thomas, Pachakkil A. Haridas Nidhina, H. C. Harsha, Akhilesh Pandey, Gopalakrishnapillai Anilkumar and T. S. Keshava Prasad

Leptin, a peptide hormone, regulates endocrine function and maintains body weight homeostasis by regulating food intake and energy expenditure via hypothalamus-mediated effects. Impairment in leptin signaling induces obesity, a major health problem worldwide. Leptin signaling regulates other physiological processes such as angiogenesis, hematopoiesis and also has effects on the reproductive, cardiovascular and immune systems. Despite its biomedical importance, a comprehensive catalog of the signaling events activated by leptin is not available as a public resource. Therefore, we initiated cataloging of the molecular reactions in this pathway to develop a detailed reaction map of leptin signaling. For the benefit of scientific community, we provided the leptin signaling pathway through NetPath (http://www.netpath.org), a freely accessible pathway resource previously developed by our group. We anticipate that leptin/leptin receptor signaling map and the data comprising these signaling events will enable future biomedical investigations.