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A New Way to Improve Male Reproductive Ability through Gut Microbiome Regulation

Zuogang Xie, Yan Wang

The research of intestinal flora in the field of male infertility is still in its infancy. The author reviewed the relationship between male fertility and intestinal microbiome imbalance in his previous article. There is evidence that the imbalance of intestinal microbiome will change the function and anatomical structure of intestinal barrier, leading to low-grade inflammation, metabolic disorder, endocrine disorder, insulin resistance, which will affect the mechanism of spermatogenesis. It seems that supplementing probiotics, prebiotics and Fecal Microbiota Transplantation (FMT) treatment can have a beneficial impact on patients with male fertility disorder. At present, this field has become a research hotspot. It is necessary to update and supplement new ideas and new treatment concepts.