Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
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A Successful Healthy Childbirth After Late Rescue Intracytoplasmic Sperm Injection Of Unfertilized Oocytes In Conventional In Vitro Fertilization

Claudia Massarotti, Sara Stigliani, Fausta Sozzi, Ida Casciano, Paola Anserini, Paola Scaruffi*

The incidence of unexpected total fertilization failure in a conventional in vitro fertilization (IVF) cycle ranges from 5% to 20%. One strategy to avoid cycle cancellation is the re-injection of unfertilized oocytes by the so-called “rescue” intracytoplasmic sperm injection (ICSI). This paper aims to report the validity of performing a rescue ICSI after a total fertilization failure in IVF. On May 2017 a 39-year-old woman presented to our Center. After standard controlled ovarian stimulation, four oocytes were retrieved and inseminated by conventional IVF. No oocytes were fertilized 18 hours after insemination. After 3 hours a rescue ICSI was performed and after 18 hours three oocytes had extruded the second polar body and showed two pronuclei. Twenty-four hours later three embryos were developed and transferred to the uterus. A single, uneventful, full-term pregnancy resulted in the delivery of a healthy girl.

In conclusion, hereby we described a healthy childbirth after the transfer of embryos derived from 1-day-old oocytes of a 39-year-old woman. Although the success of the rescue ICSI is still a matter of debate, this case is a further successful pregnancy that proves the validity of the procedure as worth an attempt to give the best chance to the couple in that cycle, without necessarily modify the routine procedures of the laboratory.