Журнал наномедицинских и биотерапевтических открытий
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A Targeted Drug Delivery System of Gd³⁺ for Neutron Capture Therapy against Cancer is Metalorganic Magnetic Nanoparticles

Olga V Kondrashina

A method for producing nanoparticles based Cholesteric Liquid Crystal Dispersion (CLCD) of complexed [DNA-Gd] with a high content of gadolinium ions (up to 400 mg/ml). Preparation can be stored in the laboratory for 200 days without changes in the physico-chemical properties. It is shown that the formation of nanoparticles of gadolinium ions bind to DNA molecules by interaction with both phosphate groups, and with the nitrogen bases, breaking the regular the secondary structure of DNA. It was found that the formation of nanoparticles significantly reduced solubility of double-stranded DNA and appears uncompensated positive charge on the surface of the complex, impeding its aggregation. The technique of nanoparticles based on a set CLCD [DNA-Gd], including the processing of the original particles CLCD double-stranded DNA with aqueous GdCl3. The magnetic properties of the nanoparticles, allowing maintain an active neutron diffusion exciting nuclide gadolinium directly on the hearth of a malignant tumor. Immobilization of nanoparticles performed by adsorption on macrophages defines active targeted delivery of gadolinium ions in lesions. The application of the local concentration of nanoparticles gadolinium is ~400 mg/ml, as a carrier for the neutron-exciting therapy of malignant neoplasms.