Журнал медицинских методов диагностики
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Antibodies Against Gangliosides in the Serum of Patients Suffering from Multiple Sclerosis Compared with Healthy Individuals

Euphrosyni Koutsouraki, Eleni Hatzifilippou, Thalia Kalatha, Vassiliki Costa and Stavros Baloyannis

We examined the sera of 56 patients with definite multiple sclerosis (MS) and 44 healthy individuals using ELISA, for investigating the probable correlation between IgM antibodies against GM1, GD1b and GQ1b gangliosides and clinical parameters of MS. Patients revealed pathological concentrations of the examined antibodies, while healthy controls demonstrated normal levels (p=0.0005). A probable correlation between anti-GD1b and anti-GM1 IgM levels with the progression of MS and a positive comparison between the duration and the disability have also been indicated. Further investigation should be established in order to provide insights on the potential autoantigenic role of gangliosides in MS.